Upconversion Nanoparticles for Diagnosis and Targeted Treatment of Cancer

Significant progress in the field of nanobiotechnology has contributed to the improvement of tools and methods for diagnosis and treatment of such socially significant diseases as cancer. The creation of multifunctional complexes is one of the effective tools of modern biomedicine. We created theranostic complexes based on upconversion luminescent nanoparticles and the recombinant targeted toxin DARPin-LoPE. We have demonstrated the high toxicity of the developed complexes against target tumor cells. In addition, we documented the selective accumulation of the resulting theranostic complexes in tumors characterized by overexpression of the HER2 receptor. In general, the complexes have high potential as effective tools for theranostics of oncological diseases.