Combined Photodynamic/Photothermal Cancer Therapy Accompanied by Optical Clearing

Combinedtechnology of photodynamic therapy and laser plasmon photothermal therapy accompanied by optical clearing was developed for rats with model tumors. Temperature monitoring and spectral measurements were made. Morphological studies of the tumor were performed with standard and immunohistochemical methods. In 72 hours, we observed pronounced necrotic changes in the tumor tissue. 21 days after the therapy, the tumor growth inhibition index by tumor mass was $77.4 \%$.