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An Asynchronous CMOS Current Readout With 124-dB Dynamic Range for Bioluminescence Sensing | IEEE Journals & Magazine | IEEE Xplore

An Asynchronous CMOS Current Readout With 124-dB Dynamic Range for Bioluminescence Sensing


Abstract:

This letter presents a photocurrent readout for bioluminescence detection. The design incorporates an asynchronous architecture employing a proposed capacitive feedback t...Show More

Abstract:

This letter presents a photocurrent readout for bioluminescence detection. The design incorporates an asynchronous architecture employing a proposed capacitive feedback transimpedance amplifier (C-TIA) with a self-timed reset network and an all-digital reconfigurable time-domain quantization scheme. It eliminates the need for a periodic reset signal required in conventional C-TIAs and offers a wide dynamic range (DR) of 124 dB, a nonlinearity of 1.7%, and a 1-pArms input-referred noise while drawing only 210~\mu A from a 1.8-V supply. Fabricated in a standard 180-nm CMOS technology, it occupies an area of 0.16 mm2. This design aims to facilitate in vitro NanoLuc (NLuc) luciferase-based bioluminescence sensing for biomolecule quantification at room temperature, with preliminary biological testing presented in this letter.
Published in: IEEE Solid-State Circuits Letters ( Volume: 7)
Page(s): 223 - 226
Date of Publication: 02 August 2024
Electronic ISSN: 2573-9603

Funding Agency:


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