Enhanced High-Resolution Compact Microscopy Based on the Fiber Optic Array and Microsphere

High resolution is important properties of the compact microscopy in the point-of-care testing (POCT) and management of various infectious diseases. However, the current high-resolution compact microscopy usually has complicated algorithm at the expense of real-time. This letter experimentally demonstrated a method to improve the resolution of compact microscope by employing the microsphere, in combination with the tube lens placed on the small-end of the fiber optic array (FOA) which termed MLFOA. This device achieves an impressive resolution of <430nm over a field of view (FOV) of
$430\mu $
m
$^{\mathbf {2}}$
without using any algorithm processing and film, the highest among the compact microscopes to our best knowledge. The material (refractive index, NA), the diameter, the light wavelength, immerse liquid of the microsphere is measured by using the MLFOA. The device can potentially be expandable for the point-of-care testing (POCT) detection.