Diagnostics of the Peripheral Artery Disease with use of Glucose Sensor - A Proof of Concept

It is estimated that 13 % of population over 50 years old suffer from symptomatic or asymptomatic peripheral artery disease (PAD). Ankle-brachial index (ABI) is viewed as a useful parameter in diagnostics of peripheral arterial disease, however screening tests with usage of this method are not advised. Hypoxia causes increase in lactate values and decrease in blood glucose. We hypothesize that the deficit in blood supply to the muscles of the lower limbs will manifest itself in a lower blood glucose concentration, e.g. in the toe measurement compared to the reference measurement taken in the part of the body where the blood supply is normal or slightly worse. We proposed simple method for determining the foot-toe glucose index (FTGI) based on automatic measurement of glucose concentration in a blood sample. Obtained results suggest that proposed method is more sensitive than cuff/ultrasound doppler method.