Development of an Ultra-Sensitive Magnetic-Based Biosensor; a Simulation Study

This study presents an advanced magnetic biosensor design incorporating an L-shaped ferromagnetic core with UL dimensions and an air gap replaced by highly porous aluminum or copper foam later-filled biological samples containing high-permeability ferromagnetic nanoparticles. The sensor detects specific biological molecules through magnetic field interactions. The system's electrical parameters were methodically optimized for enhanced performance. The research investigated the impact of various materials on the air gap's magnetic properties and assessed the relationships between permeability, output-induced voltage, input voltage, and input frequency. Findings indicate that using materials with higher magnetic permeability, such as Magnetite (Fe304) or Cobalt ferrite (CoFe2O4) ferrofluids, considerably improved the biosensor's performance by optimizing magnetic coupling between primary and secondary windings. This innovative magnetic biosensor holds potential for diverse applications, including medical diagnostics, environmental monitoring, and industrial process control. The study offers valuable insights into magnetic biosensor design and optimization, facilitating heightened sensitivity and selectivity in detecting target molecules.