Investigation the Binding Properties of Carbon-Dots as a Nanocarrier in Carbon-Dots - Gallic Acid Nanocomposite for Cancer Therapy

Cancer still poses a serious threat despite biomedical science advancements. However, the fast development of nanotechnology has opened a new ground in the field of nanomedicine for cancer treatment. In this study, we designed an anticancer nano-delivery system using organic Carbon-dots (CD) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (CDGA) was characterized using XRD, FTIR, SEM, NMR spectroscopy. In in vitro biological studies, human breast carcinoma (MCF-7), human hepatocarcinoma (HepG2), human gastric carcinoma (MKN-7), human colon carcinoma (HT-29) was treated with different concentrations of CD, GA, and CDGA. The CD successfully combined with GA, and the CD-GA nanocomposite showed cytotoxicity to the cancer cells. The results showed that carbon-dots is a potential candidate as a nanocarrier for cancer treatment, thus suggested further investigation with other pure anticancer drugs which has excellent anticancer activity.