Effect of Motion Sickness Drugs [Cinnarizine, Dimenhydrinate, Promethazine] on Gut Bacteria [E. coli]

Motion sickness, a common ailment stemming from a discordance between signals received by the brain from the vestibular system and visual cues, is often managed with oral medications primarily targeting nausea and vomiting. However, the effects of these drugs on the gut microbiota remain largely unexplored. This study aims to investigate the impact of motion sickness drugs, specifically Cinnarizine, Dimenhydrinate, and Promethazine, on Escherichia coli, a prevalent bacterium in the human colon. The research involves conducting experiments in stable conditions to assess the drugs’ efficacy under different gravitational forces. Growth rate analysis of E. coli under normal conditions will be compared with drug exposure, with deviations indicating potential drug effects. Findings from this research will contribute to understanding the motion sickness drugs resistance and their effects on gut microbiota, potentially informing future treatment strategies.