Simulational Study for Designing Lung on-Chip

The organ-on-chip (OOC) platform enables faster, better, and less expensive drug development, disease modeling, customized treatment, and insights into human health by providing flexibility and robustness in drug testing. Animal models, on the other hand, have failed to provide effective and efficient drug testing results since different species have distinct characteristics. Here, this study reports a lung-on-chip (LOC) aiming to mimic the basic physiological response invitro human lungs while breathing. This microfluidic device performed the mechanical movement of 3D cyclic stretching inspired by breathing movements. This device consisted of 2 parts, the fluidic, and pneumatic parts. This proposed microfluidic chip had two methods of operating, one was breathing mode and another one was medium exchange mode. The simulation of the lung-on-chip was done in Ansys workbench by using static structural and Computational Fluid Dynamics (CFD). The proposed microfluidic chip has great potential for drug testing and new drug development and has a wide range of applications.