Enhancing the Efficiency of Computational Genetic Epidemiology using Advanced Method

The incorporation of cutting-edge computational methodologies and machine learning strategies and genetic epidemiology has made tremendous strides in recent years. To speed up and refine genetic epidemiology studies, we present a new method called “Enhancing the efficiency of computational genetic epidemiology using Advanced Methods” (ECEGEM), which utilizes modern computational methods and innovative technologies. The three primary methods used by ECEGEM are Principal Component Analysis (PCA), Logistic Regression, and the determination of the Polygenic Risk Score (PRS). Using PCA, we can ensure that the underlying substructure of the population is not confounding genetic connections. Through its ability to predict the association between genetic variations and illness outcomes, Logistic Regression sheds light on the hereditary nature of a variety of conditions. Individuals may get more accurate risk estimates using PRS computation, which considers their unique genetic makeup. Logistic Regression, Random Forest, Support Vector Machines, Naive Bayes, kNearest Neighbors, and Decision Trees were some of the six classic approaches we used to evaluate ECEGEM against. It was shown that ECEGEM was much more accurate and precise than the conventional approaches. This highlights the promise of sophisticated computational methods for improving the accuracy of illness risk assessment and association research. Because of its ability to take into consideration population stratification and provide more accurate modeling and risk assessment, ECEGEM has been shown to be an effective tool in genetic epidemiology. Personalized medicine and the understanding of the genetic basis of complicated illnesses will benefit greatly from the use of cutting-edge technologies and machine learning as the field develops.