Highly Conductive and Environmentally Stable Mxene-Ti3C2Tx Nanosheets for Multiplexed Disease Inflammatory Biomarker Detection

This paper reports for the first time Al-rich MXene (Al-Ti
3
C
2
T
x
) nanosheets as a novel transducing material that is highly conductive and environmentally stable, as well as a new surface functionalization strategy with Ethanolamine (ETA) via the surface treatment of MXene while the ETA enhances electron transfer rate to improve the electrochemical immuno-sensing performance. The functionalized Al-Ti
3
C
2
T
x
MXene showed outstanding linearity (R
²
=0.993) with a stable response for 10 days of multiplexed disease inflammatory biomarkers such as C-reactive protein (CRP) and ferritin detection from human serum and saliva.