A Systematic Literature Review of XAI-based Approaches on Brain Disease Detection using Brain MRI Images

Brain Magnetic Resonance Imaging (MRI) analysis is a widely used medical procedure for the early diagnosis of various brain diseases. Accurate pathology identification during the brain MRI analysis procedure is crucial as misdiagnoses or missed findings can greatly affect a patient's treatment and long-term prediction. With the recent advancement of Artificial Intelligence (AI) in the medical field, researchers have approached various techniques to detect brain diseases using AI. Although AI models exhibit high accuracy, they suffer from a lack of transparency and interpretability, paving the way for the development of eXplainable Artificial Intelligence (XAI) methods in brain disease diagnosis. Image segmentation, machine learning, deep learning and XAI are important for assisting the diagnostic procedure. In this paper, a comprehensive overview of various existing techniques in brain disease detection using MRI is presented, starting with image segmentation techniques, followed by classification techniques, and finally, XAI techniques. In conclusion, the paper identifies a critical need for further research on XAI integration to advance brain disease detection.