Advancing Drug Delivery with Pocket Microneedle Achieving Dual-Drug Synchronization

This paper presents an innovative drug delivery using advanced pocket microneedle technology. The microneedle integrates two drugs: one housed inside the pocket and the other as an exterior coating. This design allows for targeted delivery of the coated drug to the skin’s surface and the pocket-contained drug to the inner layers. The exterior coating, nitric oxide-polyvinylpyrrolidone (NO-PVP), exhibits antimicrobial properties, while the pocket contains niacinamide to promote cell proliferation in deeper skin layers. Fabricated using diffraction lithography, the microneedle demonstrates precise control. Successful testing on pig cadaver skin took place to validate the design, fabrication, and dual-drug application.