Towards CMOS Capacitance Sensors for DNA Origami Characterization

This work features a novel capacitance biosensor for characterizing DNA origami. The biosensor was fabricated in a 0.18 μm CMOS process, and it consisted of an 8 × 8 array of passivated interdigitated electrodes where each electrode is coupled to a dedicated capacitance-to-frequency conversion circuit. We further show a self-referencing data acquisition scheme for reducing the variance in DNA origami measurements.