SmartFSCV: An Artificial Intelligence Enabled Miniaturised FSCV Device Targeting Serotonin

Goal:
Dynamically monitoring serotonin in real-time within target brain regions would significantly improve the diagnostic and therapeutic approaches to a variety of neurological and psychiatric disorders. Current systems for measuring serotonin lack immediacy and portability and are bulky and expensive.
Methods:
We present a new miniaturised device, named SmartFSCV, designed to monitor dynamic changes of serotonin using fast-scan cyclic voltammetry (FSCV). This device outputs a precision voltage potential between −3 to +3 V, and measures current between −1.5 to +1.5 μA with nano-ampere accuracy. The device can output modifiable arbitrary waveforms for various measurements and uses an N-shaped waveform at a scan-rate of 1000 V/s for sensing serotonin.
Results:
Four experiments were conducted to validate SmartFSCV: static bench test, dynamic serotonin test and two artificial intelligence (AI) algorithm tests.
Conclusions:
These tests confirmed the ability of SmartFSCV to accurately sense and make informed decisions about the presence of serotonin using AI.