Highly Sensitive Electrochemical Sensor Based on a Solvent-Processing Cobalt Phthalocyanine for Detection of Ascorbic Acid

The development of enzyme-free sensing materials with high performance and low cost is extremely essential in the fields of medicine, food, and chemical engineering. In this work, a solvent-processing film of 2,3,9,10,16,17,23,24-octa-(2,6-dimethylphenoxy) phthalocyaninato cobalt complex-based electrochemical sensor was prepared on a glassy carbon electrode. The CoPc(OC
$_{{8}} \text{H}_{{9}}$
)8 film is demonstrated to be a lamellar structure with a large surface area, which in turn increases the active site of ascorbic acid (AA) redox reactions, and thus presents excellent sensitivity and terrific anti-interference ability for the detection of AA with wide detection range (0.1–
$100 ~\mu \text{M}$
) and low limit of detection (LOD) (36 nM), and can selectively detect AA in milk and human serum. Because of its outstanding electrocatalytic kinetic characteristics, this present enzyme-free electrochemical sensor has a broad prospect in the application of analytical sensing of AA and it will be helpful for the design and fabrication of high-performance low-cost electrochemical sensor for trace detection of AA.