A novel fluidic network system for enzyme batch-immobilization and blood sensing

This paper reports a novel fluidic network system for immobilizing various enzymes on arrays in parallel for blood sensing. The network was fabricated by polymer-MEMS technology with plasma treatment on channel surface, and the liquids were driven by surface tension passively without external active power source. Enzyme based glucose sensing was employed as a model system in this fluidic network, and the testing result showed precise enzyme immobilization and functional sensor response. The fully fabricated glucose sensor in this fluidic network system demonstrated a sensitivity of 5.42 nA/mM, and a response linearly related to the glucose concentration. This novel fluidic network can be applied to blood sensing for clinical or domestic usage.