Bioactive Calcium Phosphate-Polymer Nerve Conduits with Carbon-Based and Magnetite Nanoparticles: HPLC study

Biodegradable tubular composites based on calcium phosphates (CaP) with natural polymer chitosan, doped with multi-walled carbon nanotubes (MWCNT+Fe), graphene oxide (GO) and magnetite (Fe
3
O
4
) in various concentrations were created. It was proved that the PG release kinetics depends on the type of inorganic nanoparticles present since the content of other components was the same. The release of pregabalin (PG) from Fe-containing samples was controlled by diffusion, whereas the release from GO-containing samples was controlled by diffusion and matrix degradation. Obtained material has the potential to improve nerve recovery, close to autograft in terms of efficiency, both due to the content of nanoparticles and the targeted release of the drug, without being toxic to other organs.