Sorbent Modified with Single-Wall Carbon Nanotubes: Evalution of Influence on Hemostatic Reaction “In Vitro”

Hemosorbents used in medicine must be safe in relation to blood cells, especially to easily vulnerable platelets. The aim of this work is to study the effect of sorbents with single-walled carbon nanotubes Al
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@ PDMS/SWNT in comparison with carbon-free sorbent Al
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@PDMS on hemostatic reactions. The study of physicochemical properties of sorbents was carried out according to standard methods. The biological properties of the sorbents were evaluated by their effect on the platelets of donor blood. The data obtained in vitro experiments revealed a decrease in the number of these cells after blood contact with both sorbents and a glass column not filled with sorbent, but both studied sorbents neutralized a hypercoagulation shift in a number of coagulogram parameters due to blood contact with a glass column. The introduction of carbon in the form of single-walled carbon nanotubes in an amount of 0.02 % into the sorbent composition enhances the sorption properties by 40 times in relation to the sorption of a marker of high-molecular molecules (vitamin B12) and is comparable in terms of the sorption of low-molecular markers (methylene blue dye) compared to a sorbent without nanotubes. The data obtained allow us to conclude that new carbon sources can be used to obtain carbon-mineral sorbents.