MoS2 Functionalized Paper Sensor for Quantification of Glucose: Experimental Observation and Ab-Initio Calculations

A paper-based electrochemical sensor has been developed for quantitative estimation of glucose concentration in spiked serum samples. Molybdenum disulphide (MoS
2
) has been hydrothermally grown over the paper substrate to detect glucose non-enzymatically. The functionalized material shows an enhanced biocatalytic activity towards the target analyte molecule; thus, an excellent electrochemical response is observed. Furthermore, the differential pulse voltammetric responses of the developed sensor show a very good recovery rate of 95.84% for spiked serum samples. The amperometric responses also confirm the specificity of the sensing platform. Moreover, a first principle analysis has been carried out to promote the suitability of MoS
2
for detection of glucose.