Development of an Optical Biosensor Based on Gold Nanoparticles

This paper describes an experimental study of SARS-CoV-2 detection using plasmonic gold nanoparticles, which overcomes the limitations of traditional detection techniques known for their time-consuming and a tendency to produce high false negative results. The transmission spectrum of gold nanoparticles (AuNPs) was recently estimated to be in filter-free wavelength sensors as a miniaturization detection system. Additionally, we demonstrate that wide-ranging absorption will manifest within the visible spectrum when the virus is partially coated with gold nanoparticles at a particular percentage of coverage. This extensive absorption can be harnessed to direct the advancement of a reliable and precise colorimetric plasmon sensor for the detection of COVID-19. The transmission value resulting from the gold nano seed is around 507–540 nm. In addition, plasmonic gold nanoparticles can detect SARS-CoV-2 well from the range of 100-1,000 ng/ml. We expect a miniaturization biosensor system with qualitative diagnosis to be realized by the development method.