Bioinformatic Analysis of BRCA for Breast, Ovary and Lung Cancer

The two most well-known genes inculpated in transcriptional control and DNA repair are breast cancer 1 and breast cancer 2, which are connected to breast tumor, ovarian tumor, and also to lung tumor. In order to elucidate mechanisms by which BRCA genes ultimately lead to the development of breast, ovarian, or lung tumors, the current study set out to clarify the expression patterns, mutational patterns, and interaction pathways of BRCA1 and BRCA2. So here in this paper bioinformatics tools have been used to analyse these two genes. FIREHOSE analysis was done to check messanger RNA levels. Breast cancer and Breast cancer 2 mutations were checked using cBioPortal study. A KM plotter study was completed to ascertain the predictive role of these genes in the chosen cancer type. After this box plot and stage plot analysis done with GEPIA2 database to check expression in four stages and for a comparison between normal tissue and tumoric tissue. STRING analysis done to show functional interaction between proteins