Development of a Fiber-Optic Spectral Domain based Optical Coherence Tomography in Near Infrared Range for Biomedical Applications

In this paper, a fiber-optic low coherence interferometry technique, in the spectral domain, is used for depth detection by considering different spectrometer resolutions from 0.1 to 2 nm. Depth resolved result from the sample was obtained for 0.1 nm resolution of the spectrometer compared to 2 nm resolution. Two glass coverslips of thickness 150 μm were used as samples. A physical depth equal to the actual thickness of the sample was estimated using the fiber-optic spectral domain low coherence interferometry. Further, the preparation of phantom which mimics the real tissue has also been illustrated for further extending this non-invasive and non-contact study using optical coherence tomography, towards the detection of skin burns or abnormalities such as skin necrosis and skin melanoma.