Robustness analysis of a fractional order control system for the hemodynamic variables in anesthetized patients

Computer-based control of anesthesia is a puzzle requiring multiple other states to be suitably monitored and controlled. Among these, hemodynamic stabilization is a must. Very few studies have been reported regarding the automatic control of the combined anesthesia-hemodynamic systems. Hemodynamic states are strongly affected by hypnotic drugs. At the same time, drugs used for hemodynamic control influence the depth of hypnosis. In this paper, a solution to maintain anesthetic and hemodynamic variables within safe operating ranges is presented and consists in a multivariable fractional order controller. The robustness of the proposed solution is analysed by considering a benchmark patient model and data from 24 patients.