Ferromagnetic Resonance Heating of Magnetic Nanoparticles Resovist for Biomedical Applications

Ferromagnetic resonance (FMR)-based magnetic energy dissipation potentially generates effective heating for cancer therapy in magnetic hyperthermia. We demonstrated the FMR characteristics of normal/customized Resovist (particle sizes of 60 and 16 nm) for biomedical applications and revealed the bias magnetic field-dependent FMR spectrum in the range of 1–10 GHz under 0–2000 Oe. Moreover, an improvement in heating power was observed under the FMR condition. The maximum temperature increment rate was 2.5 °C/s, which is tenfold greater than that of conventional magnetic hyperthermia with a frequency range of several hundreds of kilohertz. Our results indicate that magnetic hyperthermia by utilizing FMR enables the progressive study of cancer treatment.