Semi-empirical Modeling for DNA Nucleotides via Silicon Nanowire Field-effect Transistor Sensor with a Nanogap

Lately, Silicon Nanowire field-effect transistor have attracted massive attention, due to its high-sensitivity, selectivity, label-free and real-time detection capabilities. DNA detection has obtained significance increasingly through the years. Here, a novel Silicon Nanowire field-effect transistor sensor with a nanogap placed in the middle of the sensor is studied for DNA nucleotides detection purpose. The sensor results in a distinct electronic signature for each of the different DNA nucleotides (Adenosine, Guanosine Thymidine, and Cytidine). Semi-empirical model integrated with non-equilibrium Green’s function is used to analyze the DNA nucleotides detection process. The results indicate that the developed sensor could promote a novel sensing of DNA nucleotides with high accuracy.