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OMS-CNN: Optimized Multi-Scale CNN for Lung Nodule Detection Based on Faster R-CNN
The global increase in lung cancer cases, often marked by pulmonary nodules, underscores the critical importance of timely detection to mitigate cancer progression and reduce morbidity and mortality. The Faster R-CNN approach is a two-stage, high-precision nodule detection method designed for detecting small nodules, particularly in computed tomography (CT) images. This paper presents an improved ...Show More
Efficient Region Proposal Extraction of Small Lung Nodules Using Enhanced VGG16 Network Model
Yadollah Zamanidoost;Nada Alami-Chentoufi;Tarek Ould-Bachir;Sylvain Martel
2023 IEEE 36th International Symposium on Computer-Based Medical Systems (CBMS)
Year: 2023 | Conference Paper |
Cited by: Papers (1)
The efficiency of state-of-the-art convolutional networks trained to detect lung cancer nodules depends on their feature extraction model. Various feature extraction models have been proposed based on convolutional networks, such as VGG-Net, or ResNet. It has been demonstrated that such models effectively extract features from objects in an image. However, their efficacy is limited when the object...Show More
Design of a Low-Cost, Self-Adaptive and MRI-Compatible Cardiac Gating System
Ning Li;Cyril Tous;Ivan P. Dimov;Phillip Fei;Quan Zhang;Simon Lessard;An Tang;Sylvain Martel;Gilles Soulez
Objective: Cardiac gating, synchronizing medical scans with cardiac activity, is widely used to make quantitative measurements of physiological events and to obtain high-quality scans free of pulsatile artefacts. This can provide important information for disease diagnosis, targeted control of medical microrobots, etc. The current work proposes a low-cost, self-adaptive, MRI-compatible cardiac gat...Show More
Quantification and 3D Localization of Magnetically Navigated Superparamagnetic Particles Using MRI in Phantom and Swine Chemoembolization Models
Ning Li;Cyril Tous;Ivan P. Dimov;Dominic Cadoret;Phillip Fei;Yasamin Majedi;Simon Lessard;Zeynab Nosrati;Katayoun Saatchi;Urs O. Häfeli;An Tang;Samuel Kadoury;Sylvain Martel;Gilles Soulez
Objective: Superparamagnetic nanoparticles (SPIONs) can be combined with tumor chemoembolization agents to form magnetic drug-eluting beads (MDEBs), which are navigated magnetically in the MRI scanner through the vascular system. We aim to develop a method to accurately quantify and localize these particles and to validate the method in phantoms and swine models. Methods: MDEBs were made of Fe3O4 ...Show More
Quantification and 3D Localization of Magnetically Navigated Superparamagnetic Particles Using MRI in Phantom and Swine Chemoembolization Models
Ning Li;Cyril Tous;Ivan P. Dimov;Dominic Cadoret;Phillip Fei;Yasamin Majedi;Simon Lessard;Zeynab Nosrati;Katayoun Saatchi;Urs O. Häfeli;An Tang;Samuel Kadoury;Sylvain Martel;Gilles Soulez
A Piezoelectric Robotic System for MRI Targeting Assessments of Therapeutics During Dipole Field Navigation
Dipole field navigation (DFN) is a method that has been developed to deliver therapeutics toward tumoral regions by navigating microcarriers in the vascular network. To do so, DFN distorts the high uniform magnetic field of a clinical magnetic resonance imaging (MRI) scanner using precisely located ferromagnetic balls to create magnetic gradients to implement the directional forces required to nav...Show More
CMOS Optoelectronic Lock-in Amplifier with Semi-Digital Automatic Phase Alignment
2019 IEEE International Symposium on Circuits and Systems (ISCAS)
Year: 2019 | Conference Paper |
Cited by: Papers (3)
This paper presents a CMOS optoelectronic lock-in amplifier (LIA) with semi-digital automatic phase alignment for optical sensing applications. The LIA incorporates a phase sensitive detection (PSD) channel and a phase alignment channel. A phase alignment loop generates the LIA reference clock, and automatically aligns the relative phase between the reference and the input signal through a phase i...Show More
High-DR CMOS Fluorescence Biosensor With Extended Counting ADC and Noise Cancellation
Mehdi Noormohammadi Khiarak;Sylvain Martel;Yves De Koninck;Benoit Gosselin
Accurately resolving small fluorescence power variations in presence of noise and high-background tissue autofluorescence from deep brain structures with a fiber photometry system requires highly linear and sensitive photo detectors. This paper presents a high-dynamic range (DR) CMOS biosensor fusing a low-noise photosensing front-end with a high-precision extended counting analog-to-digital conve...Show More
MRI-Compatible Injection System for Magnetic Microparticle Embolization
Ning Li;Francois Michaud;Zeynab Nosrati;Dumitru Loghin;Charles Tremblay;Rosalie Plantefève;Katayoun Saatchi;Urs O. Häfeli;Sylvain Martel;Gilles Soulez
Objective: Dipole field navigation and magnetic resonance navigation exploit B0 magnetic fields and imaging gradients for targeted intra-arterial therapies by using magnetic drug-eluting beads (MDEBs). The strong magnetic strength (1.5 or 3 T) of clinical magnetic resonance imaging (MRI) scanners is the main challenge preventing the formation and controlled injection of specific-sized particle agg...Show More
A 17-bit 104-dB-DR High-Precision Low-Power CMOS Fluorescence Biosensor With Extended Counting ADC and Noise Cancellation
M. Noormohammadi Khiarak;K. Sasagawa;T. Tokuda;J. Ohta;S. Martel;Y. De Koninck;B. Gosselin
2018 16th IEEE International New Circuits and Systems Conference (NEWCAS)
Year: 2018 | Conference Paper |
Cited by: Papers (4)
This paper presents a high-dynamic range CMOS biosensor fusing a photosensing module with a high-precision extended counting analog-to-digital converter (ADC) with noise cancellation to detect florescence neural signal fluctuations of very low incident power. The 7 MSBs are resolved by a first order continuous-time resettable ΣΔ ADC, whereas the residue voltage is quantized by a 10-bit single slop...Show More
Wireless Optoelectronic Fiber Photometry Headstage for Deep Brain Structures Monitoring
M. Noormohammadi Khiarak;S. Martel;Y. De Koninck;B. Gosselin
This paper presents an optoelectronic neuroscience platform for monitoring neural dynamics in intact deep brain structures. A wireless optoelectronic headstage incorporating all aspects of a conventional benchtop high-performance optical fiber photometry system is presented to detect fluorescence signal fluctuations in the brain of live animal models. The headstage includes a photosensor, a fiber ...Show More
A Wireless Fiber Photometry System Based on a High-Precision CMOS Biosensor With Embedded Continuous-Time $\Sigma \Delta$ Modulation
Mehdi Noormohammadi Khiarak;Ekaterina Martianova;Cyril Bories;Sylvain Martel;Christophe. D. Proulx;Yves De Koninck;Benoit Gosselin
Fluorescence biophotometry measurements require wide dynamic range (DR) and high-sensitivity laboratory apparatus. Indeed, it is often very challenging to accurately resolve the small fluorescence variations in presence of noise and highbackground tissue autofluorescence. There is a great need for smaller detectors combining high linearity, high sensitivity, and high-energy efficiency. This paper ...Show More
Live Demonstration: An Energy-Efficient CMOS Biophotometry Sensor Interface
M.N. Khiarak;K. Sasagawa;T. Tokuda;J. Ohta;S. Martel;Y. De Koninck;B. Gosselin
2018 IEEE International Symposium on Circuits and Systems (ISCAS)
Year: 2018 | Conference Paper |
Cited by: Papers (1)
Implantable wireless fiber biophotometry is one of the most effective technique to monitor specific cell types through Ca2+ fluorescence sensing in live animals by avoiding fiber tethering and risks of breakage and injury which can occur in conventional apparatus. This demonstration will show the visitors a novel low-power, light-weight, and minimally invasive wireless optoelectronic interface ena...Show More
An Energy-Efficient CMOS Biophotometry Sensor With Incremental DT-∑Δ ADC Conversion
M. N. Khiarak;K. Sasagawa;T. Tokuda;J. Ohta;S. Martel;Y. De Koninck;B. Gosselin
2018 IEEE International Symposium on Circuits and Systems (ISCAS)
Year: 2018 | Conference Paper |
This paper presents a high-sensitivity incremental discrete time ΣΔ analog-to-digital converter (ADC) with variable clock and on-chip decimation for biophotometry sensing. A digital correlated double sampling (CDS) scheme is merged with the decimation filter for providing energy- and area-efficient mean to suppress low-frequency noise. Chopper modulation and differential sensing using a dummy phot...Show More
Evaluation of the Potential of Dipole Field Navigation for the Targeted Delivery of Therapeutic Agents in a Human Vascular Network
IEEE Transactions on Magnetics
Cited by: Papers (12)
Magnetically guided agents in the vascular network are expected to enable the targeted delivery of therapeutics to localized regions while avoiding their systemic circulation. Due to the small size of the medically applicable superparamagnetic microscale agents required to reach the smaller arteries, high magnetic fields and gradients are required to reach saturation magnetization and generate suf...Show More
A high-sensitivity CMOS biophotometry sensor with embedded continuous-time ΣΔ modulation
Mehdi Noormohammadi Khiarak;Sylvain Martel;Yves De Koninck;Benoit Gosselin
2017 IEEE International Symposium on Circuits and Systems (ISCAS)
Year: 2017 | Conference Paper |
Cited by: Papers (7)
This paper presents a new biophotometry sensor embedding two individual building blocks, namely a low-noise sensing front-end and a 2nd order continuous-time ΣΔ modulator (CTSDM), into a single module for enabling high-sensitivity and high energy-efficiency photo-sensing. In particular, a differential CMOS photodetector associated with a differential capacitive transimpedance amplifier (DCTIA)-bas...Show More
A high-precision CMOS biophotometry sensor with noise cancellation and two-step A/D conversion
M.N. Khiarak;K. Sasagawa;T. Tokuda;J. Ohta;S. Martel;Y. De Koninck;B. Gosselin
2017 15th IEEE International New Circuits and Systems Conference (NEWCAS)
Year: 2017 | Conference Paper |
Cited by: Papers (11)
Fluorescence biophotometry measurements require wide dynamic range (DR) and high sensitivity laboratory apparatus. Indeed, it is often very challenging to accurately resolve the small fluorescence variations in presence of high background tissue autofluorescence. There is a great need for smaller detectors combining high linearity, high sensitivity, and high-energy efficiency. This paper presents ...Show More
Seeking optimal magnetic core shapes for strong gradient generation in Dipole Field Navigation
2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)
Year: 2017 | Conference Paper |
Cited by: Papers (2)
Dipole Field Navigation (DFN) has been proposed previously as a promising remote magnetic actuation method for the navigation of microscale agents in vascular networks for the targeted delivery of therapeutics. This method exploits the strong magnetic field of a magnetic resonance imaging scanner to bring the agents at saturation magnetization, and relies on the proper positioning of ferromagnetic...Show More
Indirect MPI-based detection of superparamagnetic nanoparticles transported by computer-controlled magneto-aerotactic bacteria
Kévin Gagné;Charles Tremblay;Yasamin Majedi;Mahmood Mohammadi;Sylvain Martel
2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)
Year: 2017 | Conference Paper |
MC-1 strain magneto-aerotactic bacteria recently used in cancer therapy and labeled with superparamagnetic nanoparticles are localized by magnetic particle imaging (MPI) spectrometry. A 8.5 mT drive field oscillating at 150 kHz is generated in a solenoid coil and placed near two receiving coils connected in series in a gradiometric configuration. The magnetic behavior of superparamagnetic particle...Show More
Characterizations of magnetotactic bacteria conjugated versus unconjugated with carboxylate-Functionalized superparamagnetic iron oxide nanoparticles for tumor targeting purposes
Yasamin Majedi;Dumitru Loghin;Mahmood Mohammadi;Sylvain Martel
2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)
Year: 2017 | Conference Paper |
Cited by: Papers (1)
Targeted drug delivery through the use of swimming microorganisms known as Magnetococcus marinus MC-1 magnetotactic bacteria (or MTB) [1] acting as nanorobots loaded with therapeutic agents has been demonstrated [2]. While the role of magnetic nanoparticles (MNPs) in medicine and more specifically drug delivery enhancement is generally known [3], this study aims to couple the previously mentioned ...Show More
Trajectory planning for vascular navigation from 3D angiography images and vessel centerline data
2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)
Year: 2017 | Conference Paper |
Cited by: Papers (6)
A recently introduced method for robotic vascular catheterization is Fringe Field Navigation (FFN). A requirement of this method is the trajectory required for planning the sequences of navigation. We have introduced a method of trajectory planning compatible with the requirements of FFN for vasculature navigation. The method exploits the vessel centerline to define the vascular structure trajecto...Show More
Combining oscillating flow and clinical MRI gradients for targeted therapy
2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)
Year: 2017 | Conference Paper |
Cited by: Papers (7)
In this paper, a method based on an oscillating flow consisting of an 8 Hz vibrating flow and a constant flow used to increase the manipulation capability of particles in liquid is developed and demonstrated. The method was integrated with magnetic resonance navigation (MRN) for targeted manipulation. Micro particles encapsulating superparamagnetic nanoparticles were successfully navigated in a Y-...Show More
Magnetotactic bacteria as micro-carriers of thermal ablation agents
2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)
Year: 2017 | Conference Paper |
Intravenous systemic injection of fluidMAG-PMO magnetic nanoparticles followed by hyperthermia of the brain has previously shown to be a promising method for overcoming the blood-brain barrier; the great challenge of drug delivery to the brain. This study explores the possibility of utilizing magnetotactic bacteria as micro-carriers for fluidMAG-ARA magnetic nanoparticles as means of direct target...Show More
A CMOS lock-in-amplifier with semi-digital automatic phase tuning
2016 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Year: 2016 | Conference Paper |
Cited by: Papers (12)
A new low-power custom integrated lock-in amplifier (LIA) with semi-digital automatic phase tuning is presented. The proposed LIA leverages a new semi-digital phase tuning peripheral loop to automatically align the relative phase of a low-amplitude input signal of known carrier with that of a reference signal to increase sensitivity while decreasing the power consumption of the LIA compared with p...Show More
A Progressive Multidimensional Particle Swarm Optimizer for magnetic core placement in Dipole Field Navigation
2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
Year: 2016 | Conference Paper |
Cited by: Papers (5)
This paper tackles the inverse problem of finding optimal configurations of magnetic gradient sources in Dipole Field Navigation (DFN), a magnetic navigation method proposed recently for the direct targeting of drugs. In DFN, a limited number of these gradient sources, called the cores, must be positioned properly around a patient in a Magnetic Resonance Imaging scanner to induce the required dire...Show More
Magnetic Fringe Field Navigation of a guidewire based on Thin Plate Spline modeling
2016 IEEE International Conference on Automation Science and Engineering (CASE)
Year: 2016 | Conference Paper |
Cited by: Papers (4)
Fringe Field Navigation (FFN), a method first introduced by our group, aims at providing a high directional pulling force on a magnetic object such as a magnetic tip of a guidewire or other instruments. In a clinical setting, the pulling force is typically produced by the strong fringe field generated by the superconducting magnet of a clinical Magnetic Resonance Imaging (MRI) scanner. Because it ...Show More
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