Design and assembly of a sterile nanoscale orthopedic biomaterial

This paper details the design and manufacture of a synthetic biomimetic bone biomaterial. The material is a composite of collagen fibrils and nanometer sized mineral apatites to enhance its resorbability over previous hydroxyapatite ceramics and bone cements. An aseptic protocol for producing a sterile composite has been developed and tested. It is now possible to use this biomaterial in cell experiments.