Automatic Breast Mass Segmentation and Classification Using Subtraction of Temporally Sequential Digital Mammograms

Objective: Cancer remains a major cause of morbidity and mortality globally, with 1 in 5 of all new cancers arising in the breast. The introduction of mammography for the radiological diagnosis of breast abnormalities, significantly decreased their mortality rates. Accurate detection and classification of breast masses in mammograms is especially challenging for various reasons, including low contrast and the normal variations of breast tissue density. Various Computer-Aided Diagnosis (CAD) systems are being developed to assist radiologists with the accurate classification of breast abnormalities. Methods: In this study, subtraction of temporally sequential digital mammograms and machine learning are proposed for the automatic segmentation and classification of masses. The performance of the algorithm was evaluated on a dataset created especially for the purposes of this study, with 320 images from 80 patients (two time points and two views of each breast) with precisely annotated mass locations by two radiologists. Results: Ninety-six features were extracted and ten classifiers were tested in a leave-one-patient-out and k-fold cross-validation process. Using Neural Networks, the detection of masses was 99.9% accurate. The classification accuracy of the masses as benign or suspicious increased from 92.6%, using the state-of-the-art temporal analysis, to 98%, using the proposed methodology. The improvement was statistically significant (p-value < 0.05). Conclusion: These results demonstrate the effectiveness of the subtraction of temporally consecutive mammograms for the diagnosis of breast masses. Clinical and Translational Impact Statement: The proposed algorithm has the potential to substantially contribute to the development of automated breast cancer Computer-Aided Diagnosis systems with significant impact on patient prognosis.