Power and Accuracy Optimization for Luminescent Transcutaneous Oxygen Measurements

Transcutaneous oxygen sensing is a noninvasive method for continuous monitoring of partial pressure of oxygen diffused through the skin that closely correlates with changes in arterial blood gases. A method for measuring transcutaneous oxygen, suitable for a wearable device, is luminescence oxygen sensing. This study aims to determine the optimum values of the system parameters for power, accuracy, and precision for the development of transcutaneous oxygen wearable based on a platinum-porphyrin film and the ADPD4101 analog front-end. For this purpose, we conducted several experiments using the CN0503 optical measurement system from Analog Devices, Inc. Based on the optimization experiments, we determined a 100 mA and 100 $\mu$s LED pulse intensity and width, and a 2 $\mu$s sampling period gave a good compromise between power and signal integrity. Using these settings, we observed a discernible $\tau$ response to changes in oxygen pressure from 0 to 418 mmHg.