High-Voltage Pulse Generators for Electroporation Applications: A Systematic Review

In recent years, the use of electroporation process has attracted much attention, due to its application in various industrial and medical fields. Electroporation is a microbiology technique which creates tiny holes in the cell membrane by the applied electric field. The electroporation process needs high-voltage pulses to provide the required electric field. To generate high-voltage pulses, a pulse generator device must be used. High-voltage pulse generators can be mainly divided into two major groups: Classical pulse generators and power electronics-based pulse generators. As their name suggests, the first group is associated with the primary and elementary pulse generators like Marx generators, and the second group is associated with the pulse generators that have been updated with the advancement of power electronics like Modular Multilevel Converters. These two major groups are also divided into several subgroups which are reviewed in detail in this paper. This study reviews the literature presented in the field of pulse power and pulse generators proper for the electroporation process and addresses their strengths and weaknesses. Several tables are provided to highlight and discuss the characteristics of each subgroup. Finally, a comparative study among different groups of pulse generators is performed which is followed by a classification performance analysis.