Larvicidal activity of 1,3,4- oxadiazole analogues and their Molecular Docking Studies

A new series of 2-(5-bromo-2-(trifluoromethoxy)phenyl)-5-aryl-1,3,4-oxadiazole 4a-4h compounds (aryl = C
6
H
5
, p-ClC
6
H
4
, p-NO
2
C
6
H
4
, C
5
H
4
N, p-OCH
3
C
6
H
4
, p-BrC
6
H
4
, p-OHC
6
H
4
, p-CH
3
OC
6
H
4
) were synthesiazed by recting acid hydrazide with 5-bromo-2-(trifluoromethoxy) benzoic acid in POCl
3
. The new synthetic approach concluded with good results. The structure of synthesized Oxadiazole derivatives have been confirmed by Fourier transform infrared spectroscopy, Proton nuclear magnetic resonance and Carbon-13 NMR spectroscopy. The intention of this study to evaluate strong larvacidal activity of synthesized compounds towards Culex quinquefasciatus mosquitoes. The outcomes indicated that larvacidal activity of the synthesized compounds due to the existence of groups in the phenyl ring present of oxadiazole derivatives.