Identification of left ventricular model parameters

Simulations with a model of left ventricular pressure generation consisting of time-varying elastance, resistance, series-elastance, and deactivation were fitted to pressure curves measured in the isolated rabbit ventricle. For constant ejection flows, a fit with a RMS error of 2.78 mmHg was obtained provided that deactivation was actually incorporated in the model. Deactivation was assumed to depend linearly on end ejection pressure. Resistance was found to be independent of volume.<>