Chronic Kidney Failure Animal Model Selection for Autonomous Wearable Apparatus for Continuous Peritoneal Dialysis

Renal replacement therapy (RRT) is a set of different methods that provides an adequate blood filtration and exceed water removal from patients with chronic kidney failure. In order to increase the RRT quality and continuity of the procedure a wearable apparatus for peritoneal dialysis with dialysate regeneration was developed. However, this device requires preliminary animal testing before it finds any application in medical practice. In order to test it an adequate animal model has to be chosen. Since preliminary testing for this type of medical equipment is not a trivial task, multiple animal models should be consider for adequate apparatus estimation. In this article the possibility of different animal models application for wearable apparatus for peritoneal dialysis testing was investigated. The following animal models were evaluated: dogs, pigs, rabbits and rats. The influence of the apparatus on presented animal models was investigated.