Feasibility Study of Microsecond Pulsed Microwave Ablation Using a Minimally Invasive Antenna

In this letter, we established the feasibility of producing localized ablation zones using microsecond pulsed microwave ablation (MWA) as an alternative to conventional continuous wave (CW) MWA. We verified that a thin floating-sleeve dipole ablation probe can withstand pulsed power delivery with peak powers as high as 25 kW, with pulsewidth on the order of 1 μs. We conducted MWA experiments in egg white using CW and pulsed modes of operation and found that ablation zones achieved via pulsed MWA are comparable in dimension to those created via CW MWA when the average power and procedure duration are equivalent. Finally, we performed pulsed MWA experiments in bovine liver and confirmed that pulsed MWA consistently produces large, localized ablation zones and temperatures that exceed 100 °C. Establishing the feasibility of pulsed MWA opens the opportunity for developing a coupled MWA treatment and imaging system using pulsed MWA and microwave-induced thermoacoustic signals for real-time monitoring of MWA.