Prediction of protein – peptide binding residues using classification algorithms

Peptide-binding proteins prediction is important in understanding biological interaction, protein performance analysis, cellular processes, drug design, and even cancer prediction, so using experimental predictive methods, despite their operational capabilities, has limitations such as being costly and need to spend more time, differences between unrecognized protein structures and sequences, so design and development of computational systems for maintenance, optimal models for representing biological knowledge, management and the analysis of big biological data is so important that the authors used machine learning-based techniques such as Support Vector Machine (SVM),Random Forest (RF),Decision Tree (C4.5), Decision Tree (ID3),Gradient Boosting classifiers, which evaluated experimental results to optimize Support Vector Machine(SVM) classifier (Radial Basis Function kernel) with significant evaluation parameters such as accuracy(ACC) is equal to 0.7401 and 0.7599 for 10-fold cross validation and independent test set and also specificity (SPE) is equal to 0.7966 and 0.8088 for 10-fold cross validation and independent test set (respectively) by using various Structure-Based and Sequence-Based features.