Oxygen-Rich Plasma-Polymerized Coatings for QCM Biosensing

Thin reactive polymer surfaces are attractive in the field of bio applications, in particular, when they have the ability to bind biomolecules while providing a great level of stability in aqueous environment. Plasma polymerization techniques enable a fast and eco-friendly procedure for the preparation of thin functional polymer films. In this paper we report on the generation of highly functional oxygen-rich plasma-polymerized (pp) coatings with great level of stability in water. A quartz crystal microbalance (QCM) biosensor was successfully developed by using a plasma polymer film as a matrix layer for antibody immobilization. The developed QCM biosensor presented a stable baseline during the measurements and exhibited selective and high response to the analyte.