Mechanisms and functions of neurogenesis in the limbic system of adult animals

The need for the prevention, diagnosis and correction of strokes, the effects of injuries, neurodegenerative and other diseases of the brain requires methods of their longterm non-invasive instrumental monitoring. The work revealed individual elements of the mechanisms and functions of neurogenesis in the limbic system of adult animals. An analysis of existing data was carried out; a database was formed on the mechanisms and functions of neurogenesis in the limbic system. The visualized network is available on the Internet (http://wwwmgs.bionet.nsc.ru/mgs/gnw/genenet/viewer/adult_n eurogenesis.html). Based on bioinformation analysis, a complex of experimental studies was carried out using neurofunctional, electrophysiological, imaging and non-invasive tomographic approaches and methods. A comparison was made of control animals (living in an enriched environment) and when they were trained to solve cognitive problems. It has been confirmed that cognitive loading increases the tendency to integrate new neurons into the neural network. The appearance of asymmetry in the size of the hippocampus is shown.Such an integrated approach opens up new possibilities for multivariate analysis of the mechanisms and functions of neurogenesis, the search for tools and methods of instrumental non-invasive control in the induction of neurogenesis in order to correct the effects of injuries, strokes, neurodegenerative and other brain diseases. The norm and under the action of neurogenesis inducers. The basic mechanisms of these processes are revealed.