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A Millimeter-Scale Single Charged Particle Dosimeter for Cancer Radiotherapy | IEEE Journals & Magazine | IEEE Xplore

A Millimeter-Scale Single Charged Particle Dosimeter for Cancer Radiotherapy


Abstract:

This article presents a millimeter-scale CMOS 64 \times ,64 single charged particle radiation detector system for external beam cancer radiotherapy. A 1 \times ,1 ...Show More

Abstract:

This article presents a millimeter-scale CMOS 64 \times ,64 single charged particle radiation detector system for external beam cancer radiotherapy. A 1 \times ,1 \mathbf {\mu m^{2}} diode measures energy deposition by a single charged particle in the depletion region, and the array design provides a large detection area of 512 \times ,512 \mathbf {\mu m^{2}} . Instead of sensing the voltage drop caused by radiation, the proposed system measures the pulsewidth, i.e., the time it takes for the voltage to return to its baseline. This obviates the need for using power-hungry and large analog-to-digital converters. A prototype application-specific integrated circuit (ASIC) is fabricated in TSMC 65-nm LP CMOS process and consumes the average static power of 0.535 mW under 1.2-V analog and digital power supply. The functionality of the whole system is successfully verified in a clinical 67.5-MeV proton beam setting. To our knowledge, this is the first work to demonstrate single charged particle detection for implantable in vivo dosimetry.
Published in: IEEE Journal of Solid-State Circuits ( Volume: 55, Issue: 11, November 2020)
Page(s): 2947 - 2958
Date of Publication: 23 September 2020

ISSN Information:

PubMed ID: 33281206

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