Preparation and investigation of bioactive organic-inorganic nano-composite derived from PVB-co-VA-co-VAc/HA

Novel nano-composite composed of poly vinyl butyral co vinyl alcohol co vinyl acetate (PVB-co-VA-co-VAc) covered with bone skeleton like hydroxyapatite (HA) and coating the graphene (G) was produced through the combined phase separation technique and physical evaporation deposition (PVD) method. The chemical formula of HA is (Ca
₁₀
(PO
₄
)
₆
(OH)
₂
) and recently HA was interested for researchers as a bioactive protocol ability by substitution link of co-polymers with collagen in large specific area, high thermal stability and chemical stability, high ionic exchange capacity and ability to regenerate itself. PVB-coVA-co-VAc has strong adhesive properties with different groups such as hydroxyl group through the hydrogen bonds (non-covalent interactions), metal coordination, host-guest interactions, ionic attractions and hydrophobic reactions. The hydroxyl groups enable the PVB-co-VA-co-VAc outstanding adhesion to many substrates obtaining the metal surfaces such as calcium and phosphorus and increasing moisture resistance. PVB-co-VA-coVAc has good binding capacity on the calcium surface and it can be providing bioactive properties as well. In this case the surfaces of the specimens of nano-composite with weight percentage value (15 %) of PVB-co-VA-co-VAc was characterized by using TG/DSC, XRD, FTIR, BET, Zeta potential and in-vitro analysis. Furthermore, for the investigation mechanical properties of composite, compressive test at room temperature was utilized and the nano-composite was almost in the almost well range of improvement mechanical test. Bioactivity test (in vitro) was performed in the solution body fluid (SBF) for 14 and 30 days and the bonding between calcium and phosphate ions was created on the surface of samples and as a result the measurements were showed that nano-composite PVB-co-VA-co-VAc/HA is bioactive.