Application of Doppler ultrasound to the study of intimal hyperplasia development

Modern ultrasound techniques enable the realtime measurement of velocity profiles in vivo. Thus, it is becoming possible to correlate reliably endothelium modifications with local haemodynamics alterations. In the present paper, the importance of the wall shear rate (mean value and oscillation) on the development of intima hyperplasia is emphasized using the Moncada model for atherosclerosis as the in vivo experimental theatre.