Recording Critical Epilepsy Indicators using a Fully-Passive Wireless System

Implantable sensors for recording neural activity are often used for a variety of applications, including epilepsy studies. Current versions of these recorders are highly-invasive impractical implants and undesirable in daily life. To address this, for the first time we present a novel fully- implantable and passive system for recording characteristic epileptic activity. In this paper, we focus on recording interictal epileptiform discharges (IEDs), known indicators of clinical significance. IEDs can serve to identify the location of seizure onset zones. Notably, in the case of temporal lobe epilepsy (TLE). Here, we present IED signals recorded using neural probes previously tested with our system and demonstrated to be capable of sensing signals as low as 15 μVpp in amplitude. These recordings refer to actual animal experiments and are indicative of the broad spectrum of neural signals that can be recorded.