Development High Sensitivity Sensors Based on Surface Plasmon Resonance Phenomenon

Based on the analysis of known publications, the directions for enhancing the sensitivity of the sensor based on surface plasmon resonance are summarized. Additional porous Al
₂
O
₃
with optimal thinness 190 nm enable to take very large SPR-sensor response (10
^-2
effective refractive index change) that correspond to enhance of sensitivity in two orders. Porous SiO
_x
with optimal thinness 140 nm increase response of traditional 50 nm gold sensor by gas environment in more than 20 times, which provides an opportunity to detect the presence of harmful emissions in the atmosphere when they concentrate less than 1 mg/m
³
. Functional coating increased sensitivity of SPR sensors in 15 times, that allow us to detect a lower concentration of antibodies in samples (1% of semi-positive serum, comparing to standard methods).