Optimizing stimulus waveforms for suppressing epileptic activity reveals a counterbalancing mechanism

Electrical stimulation is used to treat drug- resistant epilepsy, and excessive stimulation can lead to adverse effects for patients. In this article, we use an extrema featured stochastic search algorithm to find energy-efficient stimulus waveforms that suppress seizure activity in two different computational models of epilepsy. We infer general principles that may provide insight into future design of energy efficient stimulus for epilepsy treatments.