Investigation of glycation products by THz time-domain spectroscopy

Glycation is the non-enzymatic reaction between reducing sugars, such as glucose, and proteins, lipids or nucleic acids. This process involvement in various pathologies of the human body, including diabetes and aging, and is an intensive field of research. Terahertz time-domain spectroscopy (THz-TDS) has been used for assay of glycation products. The transmission and the attenuated total internal reflection geometries have been used for measuring of a number glycation products in aqueous solutions at 0.2-2.5 THz.