Dynamic processes to induce LTP in hippocampalCA1 area: experiment and model

The article investigates two dynamic processes, fast and slow processes and how they effect the induction of long-term potentiation (LTP). Functionally, the fast process will work as a time window to take a spatial coincidence among various inputs projected to the hippocampus, and the slow process will work as a temporal integrator of a sequence of dynamic events. Firstly, the two factors were studied by using a "burst" stimulus and "long interval patterns" stimulus, respectively. Secondly, we propose a learning rule that for the induction of LTP there are two dynamic processes, fast and slow which are productively activated by bursts and long interval patterns. The model parameters, a time constant of short dynamics and that of long dynamics, were determined by fitting the values obtained from model simulation to the experimental data. A molecular or cellular factors with these two time constants are likely to be induced in LTP induction.