Intelligent Nanoparticle-Based Agents for Biomedical Applications: Rapid Design Using a Lateral Flow Assay

A method is developed for rapid design and easy verification of intelligent nanoparticle-based agents, which implement basic logic YES and NOT functions. The spectral-phase interferometry was used for investigation of kinetic parameters of various candidate molecules to enhance efficiency of the biomolecular interfaces responsible for logic-gating. The developed method provides a convenient powerful tool for creating theranostic agents of required performance and optimal composition before their administration to experimental animals.