Direct electromagnetic source tomographic imaging neurotechnology (DESTIN)

One of the techniques that have the greatest chance of being both high impact and disruptive is electroencephalography (EEG) because of the low cost of the device, installation, operation, and ease of use. EEG is universally used in neuroscience research. Despite its great success and demonstrated the potential for brain imaging, significant limitations exist with EEG, most important of which is the accuracy of the localization of the brain sources from the recorded EEG due to the ill-posed nature of the localization procedures which lead multiple solutions. fMRI solves this, or blood oxygen level dependent, is a well-established method for cognitive and clinical neuroscience as hemodynamic data are the epiphenomena of underlying neuronal activity developed at the Martinos Center Center. Brain mapping is one of the major endeavors that has been recently undertaken in neuroscience using fMRI to noninvasively localize the various brain functions. However, fMRI still has time resolution limitations, and subjects can only be studied in the confines of an MRI scanner. Direct Electromagnetic Source Tomographic Imaging Neurotechnology (DESTIN), may allow us to study subjects outside a scanner room and with ms second resolution needed to study neuronal activity. DESTIN is uniquely based on an entirely new physical principle which does not rely on EEG signals alone for electrical source localization rather than time of flight localization as it is similarly done in PET.