Blood glucose regulation: an output feedback approach

Diabetes mellitus is a disease that afflicts many people. Here, an output feedback for blood glucose regulation is presented. To this end, the glucose regulation problem is seen as an output tracking problem. In this way, the proposed controller leads the glucose level from diabetic to normal behavior. The resulting controller contains two parts: (I) a state estimator and (II) a linearizing-like control law. The proposed controller yields smooth control actions. Numerical simulations show that the controller is able to reject load disturbances.