Combining oscillating flow and clinical MRI gradients for targeted therapy

In this paper, a method based on an oscillating flow consisting of an 8 Hz vibrating flow and a constant flow used to increase the manipulation capability of particles in liquid is developed and demonstrated. The method was integrated with magnetic resonance navigation (MRN) for targeted manipulation. Micro particles encapsulating superparamagnetic nanoparticles were successfully navigated in a Y-shaped channel using the proposed drifting method and MRN using a magnetic gradient of 40 mT/m. The strategies and results presented in this paper envision a method for targeted drug delivery at the human scale.